Click Chemistry

Biotin-SLC-NHS Ester is membrane-permeable which allows it to be used for intracellular labeling. NHS group can react efficiently with primary amino groups (-NH2) to form stable, irreversible amide bonds. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

This is a hydrazide-activated biotinylation reagent used to label glycoproteins, carbohydrate-containing compounds that have oxidizable sugars or aldehydes. Hydrazine moiety reacts with an aldehyde to form semi-permanent hydrazone bonds. The extended spacer arm helps to minimize steric hindrance. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Gambogic acid is a natural product isolated from the resin of Garcinia hurburyi tree, Gambogic acid is a potent apoptosis inducer. It binds covalently to the regulatory subunit B (SPTSSB) of the serine palmitoyltransferase complex and inhibits de novo sphingolipid biosynthesis. Gambogic acid activates caspases in T47D breast cancer cells and inhibits binding of anti-apoptotic proteins to a BH3 peptide. Reagent grade, for research purpose.

MMAE is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. Monomethyl auristatin E or MMAE is 100-1000 times more potent than doxorubicin. It is a very potent antimitotic agent that inhibits cell division by blocking the polymerization of tubulin. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fmoc-Val-Cit-PAB-PNP is a a cleavable ADC linker used in antibody drug conjugate. The Val-Cit linker was designed to be cleaved by cathepsin B. PNP group is a good leaving group when reacting with amine bearing payload. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Monomethyl auristatin F (MMAF) is an antitubulin agent that inhibits cell division by blocking the polymerization of tubulin. Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Sulfo-Cy5-TCO is water soluble dye containing TCO moiety, which is highly reactive with tetrazines and methyltetrazines with the fastest bioconjugation speed. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Sulfo-Cy3-Methyltetrazine is a water soluble dye containing methyltetrazine moiety for the coupling with trans-cyclooctenes. Methyltetrazines possess optimal stability at physiological pH and is highly reactive towards cyclooctenes and this fluorophore is bright and very well visible with naked eye. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Sulfo-Cy5-Methyltetrazine is a fluorophore linker containing a methyltetrazine group for the TCO-ligation based labeling. Methyltetrazines possess optimal stability at physiological pH and is highly reactive towards cyclooctenes. This reagent has good aqueous solubility and stability in biological environments. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.