Chemicals

Geranylgeranyl diphosphate (GGPP) is an intermediate in isoprenoid biosynthesis. Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes fungi and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. GGPP is formed by the addition of IPP to farnesyl diphosphate catalyzed by geranylgeranyl diphosphate synthase.Provided as the tris-ammonium saltProduct Keywords: Geranylgeranyl pyrophosphate GGPPBulk discounts available please email echelon@echelon-inc.com for information. Powered by Bioz See more details on Bioz

Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes fungi and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. 1-Deoxy-D-xylulose 5-phosphate (DXP) is an intermediate in the non-mevalonate pathway and is formed from pyruvate and glyceraldehyde 3-phosphate by DXP synthase. It is converted to MEP by MEP Synthase (DXP reductoisomerase).Provided as the sodium saltAlternate Names: 1-Deoxy-D-xylulose 5-phosphate 1-Deoxyxylulose 5-phosphate Deoxyxylulose phosphate DOXP DXPBulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1) Poliquin K. Y. V. Ershov et al

Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes fungi and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway.Featured in Publications1) Dhiman R. K. et al. (2005). "1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase (IspC) from Mycobacterium tuberculosis: towards Understanding Mycobacterial Resistance to Fosmidomycin." Journal of Bacteriology 187(24): 8395-8402.Alternate Names: Deoxylulose 1-Deoxylulose 1-Deoxy-D-xyluloseBulk discounts available please email echelon@echelon-inc.com for information.

Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes fungi and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. MEP is formed from 1-deoxy-D-xylulose 5-phosphate (DXP) by MEP Synthase (DXP reductoisomerase) and coupled with CMP to form 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) by CDP-ME Synthase.Provided as the sodium saltAlternate Names: Methylerythritol phosphate 2-C-Methylerythritol 4-phosphate 2-C-methyl-D-erythritol 4-phosphate Methylerythritol 4-phosphateBulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1) Poliquin K. Y. V. Ershov e

Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes fungi and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway.Bulk discounts available please email echelon@echelon-inc.com for information.Publication Powered by Bioz See more details on Bioz1) Dhiman R. K. et al. (2005). "1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase (IspC) from Mycobacterium tuberculosis: towards Understanding Mycobacterial Resistance to Fosmidomycin." Journal of Bacteriology 187(24): 8395-8402.2) Zhang B. K. M. Watts et al. (2011). "A Second Target of the Antimalarial and Antibacterial Agent Fosmidomycin Revealed by Cellular Metabolic Profiling." Biochemistry

Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes fungi and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. 4-Diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) is an intermediate in the non-mevalonate pathway. It is formed from MEP by CDP-ME Synthase and phosphorylated at the 2-position by CDP-ME kinase to CDP-MEP.Featured in Publications1) Bernal C. E. Mendez et al. (2005). "A spectrophotometric assay for the determination of 4-diphosphocytidyl-2-C-methyl-d-erythritol kinase activity." Anal Biochem 340(2): 245-51.2) Perez-Gil J. M. Bergua et al. (2010). "Cloning and functional characterization of an enzyme from Helicobacter p

Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes fungi and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. 2-C-Methyl-D-erythritol 2 4-cyclophosphate (cMEPP) is an intermediate in the non-mevalonate pathway. It is formed by from MECDP Synthase from CDP-MEP and converted to 1-hydroxy-2-methyl-2-buten-4-yl diphosphate (HDMAPP) by IspG (GcpE).Featured in Publications1) Xiao Y. T. Savchenko et al. (2012). "Retrograde Signaling by the Plastidial Metabolite MEcPP Regulates Expression of Nuclear Stress-Response Genes." Cell 149(7): 1525.2) Zhou K. R. Zou et al. (2012). "Metabolite Profiling Identified Methylerythritol Cyclodiphospha

Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes fungi and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. 1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP or HMBPP) is an intermediate in the non-mevalonate pathway and is biosynthesized from 2-C-Methyl-D-erythritol 2 4-cyclophosphate (cMEPP) by IspG (GcpE). It is the substrate for IspH (LytB) yielding IPP and DMAPP. In addition HDMAPP is the most potent VγVδ T-cell activator identified.Provided as the tris-ammonium saltBulk discounts available please email echelon@echelon-inc.com for information.

Isopentenyl thiolodiphosphate (ISPP) is an analog of IPP in which the non-bridging oxygen has been replaced by sulfur resulting in a less-reactive compound.Provided as the tris-ammonium saltFeatured In Publications1. Phan R. M. and C. D. Poulter (2001). "Synthesis of (S)-Isoprenoid Thiodiphosphates as Substrates and Inhibitors." The Journal of Organic Chemistry 66(20): 6705.2. Lee L. V. B. Granda et al. (2010). "Biophysical Investigation of the Mode of Inhibition of Tetramic Acids the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase." Biochemistry 49(25): 5366.3. Sandoval C. M. Ayson et al. (2014) “Use of pantothenate as a metabolic switch increases the genetic stability of farnesene producing Saccharomyces cerevisiae” Metabolic Engineering 25 215-226.4. Chan YT TP Ko et al. (2017) “Crystal Structure and Potential Head-to-Middle Condensation Function of a Z Z-Farnesyl Diphosphate Synthase” ACS Omega 2(3) 930-936.Bulk discounts available please email e