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    Results for Antibiotics & Metabolites ( 2396 )

      • Ref: 10-3307
        Sizes: 1 mg, 5 mg

        Activity: Cytotoxic disulfide antibiotic . Function/Pharmacology: Displays potent broad-spectrum anticancer activity.1 Displays cytotoxic effects on mammalian cell lines (neuronal N2a cells and OLN-93 cells as model systems for nerve cells and glia) acting via disruption of mitochondrial membrane potential, activation of ERK1/2 and induction of HSP32/HO-1 (considered as a sensor of oxidative stress).2 A broad-spectrum antibiotic agent produced by marine bacteria which does not appear to induce resistance after long-term exposure.3 Chemical Name: Oxo-8,9-dithiabicyclo[5.2.0]non-1,4,6-triene-2-carboxylic acid

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      • Ref: 10-3900
        Sizes: 50 mg, 10 mg

        Activity: Antibiotic . Function/Pharmacology: Tigecycline is a clinically useful antibiotic.1,2 It is a glycylcycline derivative of minocycline that binds to the 30S ribosomal subunit of bacteria blocking the interaction of aminoacyl-tRNA with the ribosome. Tigecycline is active against Gram-positive and -negative bacteria, anaerobic bacteria and drug resistant bacteria such as MRSA, MRSE, and VRE. Tigecycline has also been shown to be selectively toxic to human acute myeloid leukemia cells over normal hematopoietic cells via inhibition of mitochondrial protein translation.3 It has also been found to be effective against other cancers including non-small cell lung cancer4, melanoma5, lymphoma6, and osteosarcoma7. Chemical Name: (4S,4aS,5aR,12aR)-9-[[2-(tert-Butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

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      • Ref: 10-4536
        Sizes: 1 mg, 5 mg

        Activity: Cholesterol metabolite . Function/Pharmacology: Metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild cognitive impairment.1,2 Endogenous selective estrogen receptor modulator3 and ligand for the liver X receptor(EC50 = 85nM for LXRα and 71nM for LXRβ)4. Chemical Name: 27-Hydroxycholesterol; 5,25R-Cholesten-3β,26-diol

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      • Ref: 10-4539
        Sizes: 5 mg, 25 mg

        Activity: Biologically active cholesterol metabolite . Function/Pharmacology: Metabolite resulting from the action of cholesterol 25-hydroxylase on cholesterol. However, since cholesterol 25-hydroxylase knock-out mice still have significant levels of 25-hydroxycholesterol there must be alternate pathways of generation that have yet to be determined.1 Likewise, the biological role of 25-hydroxycholesterol remains somewhat unclear. 25-Hydroxycholesterol is frequently mentioned as an important regulator of cholesterol metabolism, but apparently normal cholesterol regulation in organisms with both high and low levels of the compound make this association unclear. More recent reports have linked 25-hydroxycholesterol and one of it’s metabolites to immunoregulatory roles2, but more information is needed before it’s clear if that is indeed a primary role for the compound. Chemical Name: 5-Cholesten-3β, 25-diol

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      • Ref: 10-4566
        Sizes: 1 g, 250 mg

        Activity: Anti-inflammatory / antibiotic . Function/Pharmacology: Sulfasalazine is an approved drug with diverse potential applications. Sulfasalzine is a clinically useful agent for the treatment of colitis and ileocolitis.1 It is metabolized by intestinal bacteria to release the anti-inflammatory agent 5-aminosalicylic acid and the antibacterial agent sulfapyridine. It has also been found to be a specific inhibitor of NFkB (IC50 = 500 µM)2, inhibitor of IL-2 production of activated T lymphocytes3 and, TNFα and IL-1 synthesis in macrophages4. Sulfasalazine has more recently been shown to be inhibitor of the system Xc- cystine-glutamate antiporter.5,6 It was able to block cystine uptake causing depletion of glutathione resulting in compromised cellular redox defense and ultimately cessation of tumor growth. It has been studied for the treatment of breast, pancreatic, lymphoma, brain and other cancers. Chemical Name: 2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic aci

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      • Ref: BIA-R1183-1
        Sizes: 25mg
      • Ref: BIA-D1389-2
        Sizes: 25mg

        Diacetylphloroglucinol

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      • Ref: BIA-A1601-1
        Sizes: 1mg

        Amphomycin

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      • Ref: BIA-B2295-1
        Sizes: 0.5mg

        Beauveriolide III

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