Lipids

BP Lipid 227 is an amino ionizable lipid. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C5 position relative to the amine nitrogen. The primary lipid tail has 8 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Lipid A9 is an ionizable lipid that can be used to formulate lipid nanoparticles (LNPs). Lipid A9 also serves as a pH-sensitive transfection reagent. Reagent grade, for research use only.

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5-((pentadecan-7-yloxy)carbonyl)pentanoic acid is a reagent featuring a carboxylic acid and a pentanoate ester coupled to a saturated C15 tail. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

3-Hydroxy-2-(hydroxymethyl)propyl 6-bromohexanoate is a branched PEG linker with bromine and hydroxyl moieties. The alcohol groups can react to further derivatize the compound. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Palmitoleic acid is an unsaturated fatty acid that contains 16 carbon atoms and a double bond seven carbon atoms from the end of the chain. Palmitoleic acid has also been shown to have anti-inflammatory properties in vitro and in vivo, which may be due to its ability to inhibit IL-1β production by macrophages. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

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Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3. This analog of PI(4 5)P2 is labeled with the red fluorophore Cyanine 5 (Cy5)

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in several tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3.Technical Data Sheet