Lipids

Oleoyl LPA 18:1 LPA is a species of lysophosphatidic acid containing oleic acid at the sn-1 position and is the most potent LPA analog for calcium release. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.

Linoleoyl LPA 18:2 LPA is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.

Linoleoyl LPA-d5 is a deuterated analog of 18:2-LPA that can be used as a standard in mass spectrometry and lipidomics. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction.  LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion.Technical Data Sheet

Linolenoyl LPA 18:3 is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.

(2S)-Oleyl LPA is an analog of 18:1 LPA in which the fatty ester bond to gycerol has been replaced by a metabolically stable ether linkage. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion.

Arachidoyl LPA 20:0 LPA (aka Eicosanoyl LPA) is an analog of lysophosphatidic acid (LPA) a lysophospholipid involved in cell proliferation. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.

Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.

Palmitoyl dihydroxyacetone phosphate ammonium salt (Palmitoyl-DHAP) is an ether lipid implicated in cell membrane function cell signaling and is involved in lipid biosynthesis.Ether lipids have been implicated in cell membrane function and can act as signaling molecules; however their roles in cell physiology are still not completely understood. The key step for ether lipid biosynthesis is the conversion of acyldihydroxyacetone phosphate (acyl-DHAP) to alkyldihydroxyacetone phosphate (alkyl-DHAP) by the enzyme alkyldihydroxyacetone phosphate synthase (ADPS alternately referred to as AGPS). Recently elevated levels of ADPS have been found in human cancer cells and primary tumors which lead to increased levels of oncogenic signaling lipids.

Hexadecyl dihydroxyacetone phosphate ammonium salt (Hexadecyl-DHAP) is an ether lipid implicated in membrane function and is involved in lipid biosynthesis.Ether lipids have been implicated in cell membrane function and can act as signaling molecules; however their roles in cell physiology are still not completely understood. The key step for ether lipid biosynthesis is the conversion of acyldihydroxyacetone phosphate (acyl-DHAP) to alkyldihydroxyacetone phosphate (alkyl-DHAP) by the enzyme alkyldihydroxyacetone phosphate synthase (ADPS alternately referred to as AGPS). Recently elevated levels of ADPS have been found in human cancer cells and primary tumors which lead to increased levels of oncogenic signaling lipids.