Results for Lipids ( 1077 )
Lipid C24 is an ionizable lipid that can be formulated into lipid nanoparticles for delivery of RNA. Lipid C24 LNPs containing mRNA encoding SARS-CoV-2 Spike protein generated 10X higher binding and pseudoneutralizing antibodies than DLin-MC3-DMA LNPs and showed less injection site inflammation.Reference: US 2022/0218622 A1 "Ionizable lipids and methods of manufacture and use thereof"
Lipid OA2 is an ionizable lipid which can form single component lipid nanoparticles (LNPs) for delivery of RNA. Similar to lipid-based transfection reagents like LipofectamineTM pre-formed OA2 vesicles are incubated with RNA then the mixture is directly added cells. OA2 LNPs delivered siRNA to downregulate cytokine signaling 1 (SOCS1) in mouse bone marrow dentritic cells. These SOCS downregulated DCs were used as a vaccine which reduced tumor size in a B16-OVA mouse model.