Activators & Inhibitors

4-(Benzo[d]oxazol-2-yl)aniline is a potent antitumor agent that has inhibitory activity against mammary carcinoma cell lines [1].

AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.

SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.

Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.

3-Desacetyl Cefotaxime lactone, the active metabolite of Cefotaxime, is derived from its sodium salt form, which is recognized as a third-generation cephalosporin antibiotic.

5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole, a gastric proton-pump inhibitor that effectively treats various peptic diseases[1][2]. The metabolism of Lansoprazole occurs through CYP2C19, resulting in the formation of 5-Hydroxylansoprazole.

Amino-Tri-(carboxyethoxymethyl)-methane, an ADC linker and PROTAC linker, is a cleavable PEG compound utilized for the synthesis of antibody-drug conjugates (ADCs)[1] and PEG-based PROTACs[2].

Azide-C2-SS-C2-biotin is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Azidoethyl-SS-ethylazide is a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].