Peptides & Amino Acids

[Glu2]-TRH tripeptide – pGlu-Glu-Pro-NH2 (CAS: 85541-78-2) Thyrotropin-releasing hormone (TRH) Thyrotropin-releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone that regulates the release of thyroid-stimulating hormone (TSH), as well as prolactin (for breasts growth and milk production during and after pregnancy). To obtain thyrotropin-releasing hormones, 6 pro-TRH peptides have first to be obtained from the larger preproTRH precursor (UniProt: P20396). These octapeptides are then cleaved between Arginine/Glutamine and Glutamine/Lysine residues to release 6 Gln-His-Pro-Gly peptides that will be enzymatically converted in pGln-His-Pro-NH2 peptides (pGln representing pyroglutamine). After TRH maturation (1) in neurons located in the pituitary gland, the hormone will be transported along axons (2) to reach the hypophyseal portal system via exocytosis (3). Once the thyrotrophs reached, thyrotropin-releasing hormone binds TRH-receptor (4) to enable TSH synthesis a

[Glu2]-TRH tripeptide – pGlu-Glu-Pro-NH2 (CAS: 85541-78-2) Thyrotropin-releasing hormone (TRH) Thyrotropin-releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone that regulates the release of thyroid-stimulating hormone (TSH), as well as prolactin (for breasts growth and milk production during and after pregnancy). To obtain thyrotropin-releasing hormones, 6 pro-TRH peptides have first to be obtained from the larger preproTRH precursor (UniProt: P20396). These octapeptides are then cleaved between Arginine/Glutamine and Glutamine/Lysine residues to release 6 Gln-His-Pro-Gly peptides that will be enzymatically converted in pGln-His-Pro-NH2 peptides (pGln representing pyroglutamine). After TRH maturation (1) in neurons located in the pituitary gland, the hormone will be transported along axons (2) to reach the hypophyseal portal system via exocytosis (3). Once the thyrotrophs reached, thyrotropin-releasing hormone binds TRH-receptor (4) to enable TSH synthesis a

ALPHA FACTOR SIGNALING PEPTIDE Yeast mating signaling pathway The life cycle of Saccharomyces cerevisiae, also known as the brewer’s and the baker’s yeast, is characterized by both haploid and diploid phases. Indeed, yeasts are organized in two haploid types, known as a and α cells (MATa and MATα), that can either proliferate individually, using mitosis, or fuse together to form MATa/MATα diploids. α factor - WHWLQLKPGQPMY peptide - CAS: 59401-28-4. Haploid, diploid cells For two haploid cells to mate, mating factors are needed. These pheromones induce G-Protein Coupled Receptor‘s (GPCR) conformational changes, which allow G-protein migration in the plasma membrane. GPCRs are present on both a and α yeast cells and turn into Guanine nucleotide Exchange Factors (GEF) upon G-protein release. The receptor’s « new activity » leads to guanosine diphosphate (GDP) exchange by guanosine triphosphate (GTP) on the G-protein, which will recruit STE 5 to allow Fus3 protein phosphorylation

ALPHA FACTOR SIGNALING PEPTIDE Yeast mating signaling pathway The life cycle of Saccharomyces cerevisiae, also known as the brewer’s and the baker’s yeast, is characterized by both haploid and diploid phases. Indeed, yeasts are organized in two haploid types, known as a and α cells (MATa and MATα), that can either proliferate individually, using mitosis, or fuse together to form MATa/MATα diploids. α factor - WHWLQLKPGQPMY peptide - CAS: 59401-28-4. Haploid, diploid cells For two haploid cells to mate, mating factors are needed. These pheromones induce G-Protein Coupled Receptor‘s (GPCR) conformational changes, which allow G-protein migration in the plasma membrane. GPCRs are present on both a and α yeast cells and turn into Guanine nucleotide Exchange Factors (GEF) upon G-protein release. The receptor’s « new activity » leads to guanosine diphosphate (GDP) exchange by guanosine triphosphate (GTP) on the G-protein, which will recruit STE 5 to allow Fus3 protein phosphorylation

ALPHA FACTOR SIGNALING PEPTIDE Yeast mating signaling pathway The life cycle of Saccharomyces cerevisiae, also known as the brewer’s and the baker’s yeast, is characterized by both haploid and diploid phases. Indeed, yeasts are organized in two haploid types, known as a and α cells (MATa and MATα), that can either proliferate individually, using mitosis, or fuse together to form MATa/MATα diploids. α factor - WHWLQLKPGQPMY peptide - CAS: 59401-28-4. Haploid, diploid cells For two haploid cells to mate, mating factors are needed. These pheromones induce G-Protein Coupled Receptor‘s (GPCR) conformational changes, which allow G-protein migration in the plasma membrane. GPCRs are present on both a and α yeast cells and turn into Guanine nucleotide Exchange Factors (GEF) upon G-protein release. The receptor’s « new activity » leads to guanosine diphosphate (GDP) exchange by guanosine triphosphate (GTP) on the G-protein, which will recruit STE 5 to allow Fus3 protein phosphorylation

SYFPEITHI MHC binding peptide SB-PEPTIDE offers SYFPEITHI peptide for immune reactivity studies and MHC ligand assays. Major Histocompatibility Complex (MHC) MHC is a large cluster of genes, called Human Leukocyte Antigens (HLA) in humans and H-2 complex in mice. This DNA locus of highly polymorphic genes codes for MHC molecules, present on the cell surface, whose function is to present antigens to T-cells. Foreign antigen presentation by MHC proteins triggers the appropriate T-cells to proliferate and generate a specific cellular immune response. The polygenism and polymorphism of MHC molecules make it difficult for pathogens to evade immune responses. This complex contains several different MHC class I and MHC class II genes to ensure that each individual has a unique set of MHC molecules capable of binding to a diverse range of peptides. MHC-I proteins are found on all nucleated cells, while MHC-II molecules are restricted to antigen-presenting cells (APCs). MHC bindi

SIL peptide for Adalimumab detection and quantification

Primary SIL peptide for Infliximab detection and quantification

Secondary SIL peptide for Infliximab detection and quantification