Lipids & Polymers

Bead-conjugated antibody pair compatible with Simoa® (single molecule array) and similar assays for detecting rat NF-L in various sample types. The kit includes a bottle of capture beads, a bottle of detection reagent and standards.

Poly(DL-lactide) (PDLLA) is an ubiquitous biodegradable polymer. It is typically used to fabricate medical devices that predictably degrade over months in physiological conditions. The well-researched release profile also allows for drug-release functionalization with calculable results. Owing to its extensive history, PDLLA is one of the most understood and affordable biodegradable polymers for medical devices today.

A 410099.1 amide-PEG2-amine-Boc is a functionalized IAP ligand for PROTACs, consisting of an IAP ligand and an amide-PEG3 linker with a terminal amine. It is capable of forming conjugates with target protein ligands.

PEG2000-DSPE can be used for the preparation of stabilized nucleic acid-lipid particllipid particles (SNALPs). SNALPs represent some of the earliest and best functional siRNA-ABC nanoparticles described [1] .

14:0 PEG2000 PE (DMPE-PEG2000) is a polyethylene glycol (PEG)-phospholipid coupling that prevents vesicle aggregation in the preparation of vesicle formulations and can be used to prepare nanostructured lipid carriers.

Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker employed for synthesizing antibody-drug conjugates (ADCs)[1]. It also serves as a PEG-based PROTAC linker for the synthesis of PROTACs[2].

Boc-C1-PEG3-C4-OH is an Alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs, which are characterized by their structure comprising two distinct ligands tethered by a linker. One ligand of PROTACs binds to an E3 ubiquitin ligase, while the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs facilitate the targeted degradation of specific proteins[1].

Pomalidomide-PEG1-C2-N3 is a compound that has been synthesized as a conjugate of an E3 ligase ligand-linker. This compound incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, which are commonly used in PROTAC technology. Utilizing Pomalidomide-PEG1-C2-N3, it is possible to design a selective CDK6 PROTAC degrader known as CP-10. CP-10 effectively induces the degradation of CDK6, displaying a DC50 value of 2.1 nM[1].