Activators & Inhibitors

(S,R,S)-AHPC-amido-C5-acid is a chemical compound that contains a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. It can be utilized in the design of XY028-133[1].

(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate that functions as a ligand-linker for E3 ligases. This compound incorporates a VHL E3 ligase linker and MS432, derived from the MEK1/2 inhibitor PD0325901[1].

(S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-XL PROTAC degraders[1].

SMPT, a non-cleavable ADC linker, is utilized in the production of antibody-drug conjugates (ADCs)[1].

SNPB is a cleavable linker that is used for making antibody-drug conjugate (ADC).

SPDMV is a glutathione-cleavable linker utilized in antibody-drug conjugates (ADCs)[1].

TCO-OH is a alkyl chain-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thalidomide-NH-C6-NH2 TFA is a synthetic conjugate compound that combines a cereblon ligand based on Thalidomide with a linker used in PROTAC technology, functioning as an E3 ligase ligand-linker conjugate[1].

1,4-Dichloro 5-carboxytetramethylrhodamine is a fluorescence labeling agent (Ex: 541 nm, Em: 568 nm).