Lipids & Polymers

14:0 PEG2000 PE (DMPE-PEG2000) is a polyethylene glycol (PEG)-phospholipid coupling that prevents vesicle aggregation in the preparation of vesicle formulations and can be used to prepare nanostructured lipid carriers.

Gly-Gly-Gly-PEG4-azide functions as a cleavable linker for antibody-drug conjugates (ADCs), facilitating their synthesis [1].

Pomalidomide 4'-PEG5-amine, a cereblon ligand designed for PROTAC research and development, features an integrated E3 ligase ligand and a PEG5 linker ending in an amine for easy conjugation to target protein ligands. It is among a series of functionalized tool molecules specifically crafted for PROTAC R&D.

Aminooxy-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

APN-C3-PEG4-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker employed for synthesizing antibody-drug conjugates (ADCs)[1]. It also serves as a PEG-based PROTAC linker for the synthesis of PROTACs[2].

Biotin-PEG5-amine is a PEG-based PROTAC linker labeled with biotin. It is utilized in the synthesis of PROTACs, a class of molecules with the ability to target and degrade specific proteins[1].

Mal-PEG3-NHS ester, a noncleavable ADC linker, possesses a Maleimide group. It serves as a crucial component in the synthesis of antibody-drug conjugates[1].

Boc-C1-PEG3-C4-OH is an Alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs, which are characterized by their structure comprising two distinct ligands tethered by a linker. One ligand of PROTACs binds to an E3 ubiquitin ligase, while the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs facilitate the targeted degradation of specific proteins[1].