Activators & Inhibitors

KIF18A-IN-4 is a moderately potent non-competitive KIF18A inhibitor of ATP and microtubule with an IC50 of 6.16 μM. KIF18A-IN-4 selectively acts on a large number of mitotic kinesins and kinases, with no direct effect on microtubule protein assembly. KIF18A-IN-4 shows anti-tumour effects.

Lasofoxifene (CP-336156) is a selective, orally active estrogen receptor modulator (SERM) that inhibits the growth and metastasis of primary tumours and is also anti-osteoporotic.

Antibacterial agent 79 is an antibacterial agent.

Tubulin polymerization-IN-3 is a potent inhibitor of microtubulin polymerization (IC50: 3.84 μM) and induces apoptosis in colon cancer cells.

Chitinase-IN-5 (8i) is a potent inhibitor of the chitinase OfChi-h (IC50: 0.051 μM) and has good insecticidal properties.Chitinase-IN-5 can be used to study green pest control and management.

FNDR-20123 is the first safe and effective anti-malarial HDAC inhibitor, acting on both Plasmodium falciparum HDAC (IC50: 31 nM) and human HDAC (IC50: 3 nM). FNDR-20123 inhibited HDAC1 (IC50: 25 nM), HDAC2 (IC50: 29 nM), HDAC3 (IC50: 2 nM), HDAC6 (IC50: 11 nM), HDAC8 (IC50: 282 nM) and, at nanomolar concentrations, HDAC3 (IC50: 2 nM). The inhibitor of HDAC subtype III was also observed at nanomolar concentrations.

Anticancer agent 80 (Compound 3c) is an anticancer agent that exhibits a significant dark toxic effect on T47-D (IC50: 10.14 μM).

Colistin adjuvant-1 is a mucin adjuvant with enhanced mucin-enhancing activity against gram-negative bacteria. colistin adjuvant-1 exhibits inhibition of NF-κB (IC50: 0.209 μM).

(Rac)-NMDAR antagonist 1 is a racemate of NMDAR antagonist 1. NMDAR antagonist 1 is a potent, orally active, NR2B-selective NMDAR antagonist.