Nucleic Acids

3'-OMe-U-2'-phosphoramidite is a nucleoside phosphoramidite containing a uracil nucleoside with a 3'-OMe group, and it can be employed for DNA and RNA synthesis.

3'-F-3'-dG(iBu)-2'-phosphoramidite is a purine nucleoside amidite analog that can be subjected to facilitate the making of DNA or RNA.

5-Formylindole-CE Phosphoramidite is a versatile aldehyde modifier that facilitates electrophilic substitution in oligonucleotides by reacting with amino groups to form Schiff's bases, hydrazino groups to create hydrazones, and semicarbazides to generate semicarbazones, enhancing their functionality.

The DMTr-LNA-G(iBu)-3'-CED-phosphoramidite is a pivotal component in Locked Nucleic Acid (LNA) oligonucleotide synthesis. It features a ribonucleoside connected through a methylene unit between the 2’-oxygen and 4’-carbon atoms, mirroring DNA polymer synthesis.

DMTr-2',2'-difluoro-dC(Bz)-3'-CED-phosphoramidite is a nucleoside phosphoramidite vital for oligonucleotide synthesis. Opting for chemical over enzymatic synthesis enables rapid production of customized oligonucleotides. These sequences are typically constructed 3’ to 5’. This amidite helps in facilitating gene silencing experiments, as shown by its use in substituting gemcitabine for cytidine within an oligonucleotide sequence.

DMTr-LNA-A(Bz)-3-CED-phosphoramidite is a Locked Nucleic Acid (LNA) phosphoramidite, which is a bicyclic amidite where a ribonucleoside is linked between the 2’-oxygen and the 4’-carbon atoms with a methylene unit.

1-[(5E)-3-O-[(Bis-diisopropyl amino)(2-cyano ethoxy)phosphino]-5,6-dideoxy-6-(diethoxy phosphinyl)-2-O-(2-MOE)-β-D-ribo-hex-5-enofuranosyl]uracil, containing a 2'-O-MOE-modified uridine nucleoside, can be used to form antisense RNA. The 2'-MOE backbone enhances duplex stability and nuclease protection.

Bz-5-Me-C-LA-CE Phosphoramidite is a Locked Nucleic Acid (LNA) phosphoramidite, which is a bicyclic amidite where a ribonucleoside is linked between the 2’-oxygen and the 4’-carbon atoms with a methylene unit. This amidite is integral to Locked Nucleic Acid (LNA) oligonucleotide synthesis, following a parallel process to DNA polymers.

DMTr-LNA-5MeU-3-CED-phosphoramidite is vital for Locked Nucleic Acid (LNA) oligonucleotide synthesis, which features a ribonucleoside connected by a methylene unit between 2’-oxygen and 4’-carbon atoms, mirroring DNA polymerization in structure and process.