Cells

Human sensory neurons derived from iPSC (Caucasian, 2M cells). For French customers only.

The AC16 cell line, derived from human ventricular cells fused with SV40-transformed, uridine-auxotroph fibroblasts, showcases characteristics of cardiomyocytes, including the expression of transcription factors GATA4, MYCD, NFATc4, and contractile proteins like alpha- and beta-myosin heavy chain. These cells also express gap junction proteins connexin-43 and connexin-40, with functional gap junctions confirmed by dye-coupling studies. When the SV40 oncogene is silenced, AC16 transitions towards a differentiated state, marked by the expression of BMP2, indicative of cardiac differentiation. AC16 cells' ability to mimic cardiomyocyte behavior, including cessation of proliferation and formation of multinucleated syncytia under specific conditions, makes it a valuable model for cardiac research. It retains the genetic material of primary cardiomyocytes, allowing for studies on cardiac development and pathology in vitro, bridging gaps in understanding heart disease mechanisms and potential

Human Motor Neurons (iPSC-derived, Amyotrophic Lateral Sclerosis Patient, Sporadic)

Human Motor Neurons (iPSC-derived, Amyotrophic Lateral Sclerosis Patient, Sporadic)

Human Motor Neurons (iPSC-derived, TDP43 mutation, N352S, HET)

Human Motor Neurons (iPSC-derived, TDP43 mutation, N352S, ISO)

Human Motor Neurons (iPSC-derived, TDP-43 mutation, Q331K, ISO)

Human Motor Neurons (iPSC-derived, TDP-43 mutation, Q331K, ISO)

Human Motor Neurons (iPSC-derived, TDP43 mutation, Q331K, HOM)